Selected Publications

For a complete listing of publications click here.

Influence of obesity on nutrient metabolism

Hyogo H, Roy S, Paigen B, Cohen DE. Leptin promotes biliary cholesterol elimination during weight loss in ob/ob mice by regulating the enterohepatic circulation of bile salts. J Biol Chem 2002:277;34117-24.  PMID: 15793852

VanPatten S, Karkanias GB, Rossetti L, Cohen DE. Intracerebroventricular leptin regulates hepatic cholesterol metabolism. Biochem J 2004;379:229-33.  PMCID: PMC1224095

Roy S, Hyogo H, Yadav S, Wu, MK, Jelicks L, Locker JD, Frank PG, Lisanti MP, Silver DL, Cohen DE. A biphasic response of hepatobiliary cholesterol metabolism to dietary fat at the onset of obesity in the mouse. Hepatology 2005;41:887-95.  PMID: 15793852

Krisko TI, Nicholls HT, Bare CJ, Holman CD, Putzel GG, Jansen RS, Sun N, Rhee K, Banks AS, Cohen DE. Dissociation of adaptive thermogenesis from glucose homeostasis in microbiome-deficient mice. Cell Metab 2020;31:592-604.  PMCID: PMC7888548

PC-TP

Roderick SL, Chan WW, Agate DS, Olsen LR, Vetting MW, Rajashankar KR, Cohen DE. Structure of human phosphatidylcholine transfer protein in complex with its ligand. Nature Struct Biol 2002;9:507-11.  PMID: 12055623

Shishova EY, Stoll JM, Ersoy BA, Shrestha S, Scapa EF, Li Y, Niepel MW, Su Y, Jelicks LA, Stahl GL, Glicksman M, Gutierrez-Juarez R, Cuny GD, Cohen DE. Genetic ablation or chemical inhibition of phosphatidylcholine transfer protein attenuates diet-induced hepatic glucose production. Hepatology 2011;54:664-74.  PMID: 21538437

Krisko TI, LeClair KB, Cohen DE. Genetic ablation of phosphatidylcholine transfer protein/StarD2 in ob/ob mice improves glucose tolerance without increasing energy expenditure. Metabolism 2017;68:145-9.  PMCID: PMC5308448

Druzak SA, Tardelli M, Mays SG, El Bejjani M, Xulie Mo X, Maner-Smith KM, Cato ML, Tillman MC, Sugiyama A, Xie Y, Fu H, Cohen DE, Ortlund EA. Ligand dependent interaction between PC-TP and PPARδ mitigates diet-induced hepatic steatosis in male mice. Nat Comm. 2023;14:2748

PC-TP & Them2

Ersoy BA, Tarun A, D’Aquino K, Hancer NJ, Ukomadu C, White MF, Michel T, Manning BD, Cohen DE. Phosphatidylcholine transfer protein interacts with thioesterase superfamily member 2 to attenuate insulin signaling. Science Signal 2013; 6:ra64. PMCID: PMC3959124

Ersoy BA, Maner-Smith K, Li Y, Alpertunga I, Cohen DE.  Thioesterase-mediated control of cellular calcium homeostasis enables hepatic ER Stress. J Clin Invest 2018;128:141-156. PMCID: PMC5749517

Imai N, Nicholls HT, Alves-Bezerra M, Li Y, Ivanova AA, Ortlund EA, Cohen DE. Up-regulation of Thioesterase Superfamily Member 2 in Skeletal Muscle Promotes Hepatic Steatosis and Insulin Resistance. Hepatology. 2022;75:154-169: PMID: 34433228.

Xie Y, Liu X, Liu W, Carr LR, Lee LP, Ortlund EA, Cohen DE. Activity and phosphatidylcholine transfer protein interactions of skeletal muscle thioesterase Them2 enable hepatic steatosis and insulin resistance. J Biol Chem 2024;300:10785.  PMID: 39369989

Them1

Zhang Y, Li Y, Niepel MW, Kawano Y, Han S, Liu S, Marsili A, Larsen PR, Lee CH, Cohen DE. Targeted deletion of thioesterase superfamily member 1 promotes energy expenditure and protects against obesity and insulin resistance. Proc Natl Acad Sci USA 2012;109:5417-22. PMCID: PMC3325675

Li Y, Imai N, Goyal S, Nicholls HT, Roberts B, Goyal S, Krisko TI, Baqai M, Ang LH, Tillman MC, Ortlund EA, Cohen DE*, Hagen SJ*. Thioesterase superfamily member 1 undergoes stimulus-coupled conformational reorganization to regulate metabolism in mice. Nat Commun 2021;12:3493. PMCID: PMC8190112 (*co-corresponding authors)

Krumm CS, Ramos-Espiritu L, Landzberg RS, Adura C, Liu X, Acuna M, Xie Y, Xu X, Tillman MC, Li Y, Glickman JF, Ortlund EA, Ginn JD, Cohen DE. High-throughput screening identifies small molecule inhibitors of thioesterase superfamily member 1: Implications for the management of non-alcoholic fatty liver disease. Mol Metab 2023;78:101832

Xu X, Mendoza A, Krumm CS, Bare CJ, Holman CD, Cortopassi M, NichollsHT, Dartigue V, Hollenberg AN, Lee AH, Hagen SJ, Cohen DE. ChREBP-mediated up-regulation of Them1 coordinates thermogenesis with glycolysis and lipogenesis in response to chronic stress. Sci Signal 2024; in press.